Approximately 3-fold greater expression of LC3-II was detected in THP-1 cells 24 h post-H37Rv infection (P < 0.005) (Fig. 2F); however, lower LC3-II expression was noted in Fn14-knockdown cells infected with H37Rv (P < 0.005) compared with that in control knockdown cells or naive (RPMI medium treatment control, solvent control [SC]) cells. This evidence concerns the gene TNFRSF12A and infection.