Proteins synthesized from transcripts that showed little or no induction in response to L. pneumophila were readily identified (Fig. 2D), and mutational inactivation of innate immune transcription driven by either type I IFN (Fig. 2B) or MyD88 recognition (Fig. 3C) did not prevent many of these proteins from being synthesized after bacterial infection. Here, MYD88 is linked to bacterial infectious disease.