Among the regulons exhibiting elevated activity in cluster 7 than cluster 8, the JNK signaling-associated AP-1 TFs Jra and kay have been previously implicated in polarity loss-induced metastatic tumor formation in the wing discs (Bunker et al., 2015; Igaki et al., 2006; Külshammer et al., 2015; Uhlirova and Bohmann, 2006). The gene discussed is MAPK8; the disease is metastatic neoplasm.