Orthologs of l(2)gl have been identified in both mice (mgl-1) (Tomotsune et al., 1993) and humans (Hugl-1) (Strand et al., 1995), and conservation of its tumor-suppressive role is supported by the observation that ectopic Hugl-1 expression could rescue l(2)gl mutant phenotype in Drosophila (Grifoni et al., 2004). Here, LLGL1 is linked to neoplasm.