TNF and neoplasm: In response to immune monitoring, multiple immune cells were found to functionally migrate to the tumor sites and trigger anti-tumor immunity through the release of a series of cytotoxic factors, such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α and CD95 ligand (FasL), and TNF-related apoptosis-inducing ligand (TRAIL) [76–78].