Importantly, we confirmed upregulation of the human homolog HSPB1 in adenoma tissues obtained from a cohort of 59 patients of which we received both adenomatous and adjacent intestinal tissue of normal macroscopic appearance, which suggests that HSPB1 upregulation in APC‐mutant cells is conserved from mouse to human (Fig 1I). This evidence concerns the gene HSPB1 and adenoma.