Studying the IDH1 structure (PDB ID 5YFN), we find that G97 is also involved in a direct interaction with isocitrate, and therefore will also likely damage enzymatic activity (Fig 2B); additionally, G97 has been previously implicated in human cancers and is known to accumulate 2‐hydroxyglutarate (Losman & Kaelin, 2013). This evidence concerns the gene IDH1 and cancer.