The importance of the nuclear envelope for cardiomyocyte function is demonstrated by loss-of-function variants in lamin A/C (LMNA), which compromise nuclear envelope integrity and lead to dilated cardiomyopathy.46,47 We speculate that the insertion of myomesins in the nuclear envelope in developing cardiomyocytes may also confer force buffering functions, thereby protecting the nucleus in the neonatal period when cardiomyocytes must divide and replicate while maintaining cardiac contraction. This evidence concerns the gene LMNA and dilated cardiomyopathy.