Rare loss-of-function and deleterious missense variants in MYOM1 and MYOM2 are associated with human cardiomyopathies, and knockout of MYOM1 in hiPSC-CMs and MYOM2 in Drosophila have deleterious effects on sarcomere structure and contractility, further indicating the functional importance of these proteins in cardiomyocytes.42–44. The gene discussed is MYOM1; the disease is cardiomyopathy.