It is discussed if patients with IgE to serum albumins should be advised to avoid mammalian pets as they may experience clinical symptoms upon contact with any pet.26 Barber et al have recently published a proposed AIT treatment algorithm for cat and dog allergy which discriminates between primary sensitization and cross-reactive sIgE response.30 Only patients sensitized to major allergens should be eligible for AIT. This evidence concerns the gene IGHE and allergic disease.