TNF and metabolic dysfunction-associated steatotic liver disease: Regardless of the origin, the chronic inflammation associated with NAFLD is believed to have a tumor-promoting effect on the body in the interplay of molecules such as NF-kB, signal transducer and activator of transcription 3 (STAT-3), and various proinflammatory cytokines, such as IL-1, IL-6, and tumor necrosis factor.