KISS1 and hypogonadotropic hypogonadism: A high-fat diet in animals has been shown to result in resistance to leptin and a fall in the expression of kisspeptin in the arcuate nucleus and third ventricular rostral periventricular area [188]. Thus central hypogonadism occurs since the decrease in kisspeptin inhibits GnRH neurons lowering gonadotropin and secretion of testosterone [9,189].