Although the studies on the components of the nonconventional axis (ACE2/Ang 1-7/Ang 1-9/AT2R and MasR) of the RAS are less than those of the conventional axis, using activators and inhibitors has shown a protective role for the ACE2, AT2R, and MasR against AKI induced by RIRI. This evidence concerns the gene ACE2 and acute kidney injury.