AT2R activation with agonist exerts a protective effect in RIRI-related cardiohepatic dysfunction as showed by inhibited oxidative stress, downregulated inflammatory cytokines such as IL-6, IL-1, IL-17A, monocyte chemoattractant protein-1 (MCP-1), and TNF-α, and improved cardiohepatic depressor arm of RAS under diabetes mellitus (DM) and nondiabetes mellitus conditions [97]. The gene discussed is IL1B; the disease is diabetes mellitus.