However, when the CVID group was analyzed, we observed a reduction in the frequency of CD69+CD137+CD4+T cells (p = 0.02), and a decreasing trend in both CD69+CD154+CD4+ (p = 0.06) and CD25+OX40+CD4+T cells (p = 0.08) from w8 to w24 (Figures 5A–5C). Here, TNFRSF4 is linked to common variable immunodeficiency.