Interestingly, detectable levels of KPNA2, DTL, BACE2 and DTYMK were not exclusive to plasma samples from metastatic/non‐resectable melanoma patients, as we also observed detectable cfRNA copies in melanoma patients with radiologically no evidence of disease (NED, N = 7, e.g., after surgical removal or complete response to drug treatment) at a similar level. Here, KPNA2 is linked to melanoma.