Further detection of changes in the expression of these innate function-associated molecules of CD4 + CD28− T cells cultured with IL-15 showed that the expression level of NKG2D in CD4 + CD28− T cells from LN patients was higher than that from the healthy controls when cells were cultured with anti- CD3, IL-15 or both (Fig. 4A). Here, IL15 is linked to lobular neoplasia.