Multiparameter flow cytometry showed that the percentage of CD4 + CD28− T cells in SLE patients was significantly higher than that in the age- and sex-matched healthy controls (14.09 ± 2.12% vs. 5.03 ± 0.95%, P = 0.0051) (Fig. 1A-B). The gene discussed is CD4; the disease is systemic lupus erythematosus.