Among the above approaches, B7-H3 CAR-T cell therapy has been used for treating a variety of solid tumors including neuroblastoma, glioblastoma, atypical teratoma/rhabdomyoma, Ewing's sarcoma, which indicated that B7-H3 was an excellent target for CAR-T cell therapy [20, 25–27]. The gene discussed is CD276; the disease is neuroblastoma.