For example, downregulation of O-GlcNAclation transferase (OGT) reduces O-GlcNAc modification of SNAP-23, thereby promoting the formation of SNARE complex composed of SNAP-23, VAMP8, and Syntaxin-4 and eventually promoting exosome biogenesis in ovarian cancer cells [141]. This evidence concerns the gene SNAP23 and ovarian carcinoma.