For the ESCRT-dependent pathway, Hoshino et al. found that oncogene Hrs promoted invadopodia formation and cell invasion in SCC61 HNSCC cells [128]; Zhong et al. reported that Hsp90, ubiquitously activated in cancer, promoted exosomal secretion of Rab22a-NeoF1 fusion protein, thereby promoting cancer metastasis in osteosarcoma cells and several other cancers [74, 75]. This evidence concerns the gene HSP90AA1 and cancer.