Of note, the ratio of CD8 + T-cells to Tregs was inversely correlated with HK2 tumor expression (lung ADC, spearman rho = −0.335, P < 0.001; lung SqCC, spearman rho = −0.236, P = 0.010; colon ADC, spearman rho = −0.175, P = 0.004) (Fig. 3B-D). Here, CD8A is linked to neoplasm.