In colon adenocarcinoma, tumors with higher T stage tended to have higher HK2 expression than tumor with lower stage (P = 0.07) and when categorizing tumors T1-3 versus T4, T4 tumors showed statistically significant HK2 overexpression, compared to T1-3 tumors (P = 0.015, data not shown). Here, HK2 is linked to neoplasm.