In contrast, Treg infiltration was positively correlated with tumoral HK2 expression in lung adenocarcinoma and squamous cell carcinoma cohort (lung ADC, spearman rho = 0.489, P < 0.001; lung SqCC, spearman rho = 0.306, P = 0.001), and tended to be positively correlated with tumoral HK2 expression in colon adenocarcinoma cohort (spearman rho = 0.111, P = 0.054) (Fig. 3B-D). This evidence concerns the gene HK2 and lung adenocarcinoma.