IQGAPs were altered in 69 of 366 HCC patients (18.9%), where IQGAP1, IQGAP2, and IQGAP3 were altered in 3, 1.9, and 14% of the queried HCC samples, respectively (Fig. 4A). The gene discussed is IQGAP2; the disease is hepatocellular carcinoma.