Moreover, ROS species produced by cytochrome b-245, beta polypeptide (CYBB, best known as NOX2) have been mechanistically implicated in the ability of experimental melanomas to form metastasis via a mechanism that (1) is manifest only in immunocompetent (but not IFGN deficient) hosts, and (2) involves NK cell dysfunction [116]. The gene discussed is CYBB; the disease is melanoma.