HAVCR2 and sarcoma: Specifically, CD73+ NK cells infiltrating breast carcinomas and sarcomas have been shown to express a number of immunosuppressive molecules including (but not limited to) PD-L1, PD-1, lymphocyte activating 3 (LAG3), hepatitis A virus cellular receptor 2 (HAVCR2, best known as TIM-3) and T cell immunoreceptor with Ig and ITIM domains (best known as TIGIT) [158], correlating with abundant secretion of immunosuppressive cytokines such as IL10 and TGFB1 [156].