ERBB2 and breast cancer: Similar results have been obtained with an activator of NFE2 like bZIP transcription factor 2 (NFE2L2, a master regulator of antioxidant responses best known as NRF2) [121] in NK cells from healthy donors [122], as well as by engineering CAR-expressing T cells specific for erb-b2 receptor tyrosine kinase 2 (ERBB2, best known as HER2) to overexpress CAT, which resulted not only in superior cytotoxicity against HER2-expressing mammary tumors, but also in preserved bystander cytotoxicity by otherwise ROS-sensitive NK cells [123].