Moreover, we have previously shown in a mouse model of experimental periodontitis (EP) that treatment with MSE accelerates bone healing, and can even reverse bone loss (even when the etiologic factors used in EP remain present) and that these effects are related to decreases in local oxidative stress-related damage and upregulated the master regulation of antioxidants nuclear factor erythroid 2-related factor 2 (Nrf2) activity [21]. Here, NFE2L2 is linked to periodontitis.