CD274 and cancer: Another phase I/II clinical trial using combined PD-1, BRAF and MEK inhibition indicated that spartalizumab (anti-PD-L1) plus dabrafenib and trametinib led to an ORR of 78%, including 44% complete responses (CRs), highlighting glycolysis-inhibiting trametinib is an important reagent for cancer therapy and an adjuvant candidate to immunotherapy [342].