Ham et al. explored that nuclear PKM2 could suppress the E-cadherin expression by binding with TGF-β-induced factor homeobox 2 (TGIF2) and HDAC3 to induce the deacetylation of histone H3 in the promotor sequence of E-cadherin in colon cancer cells [121]. Here, CDH1 is linked to malignant colon neoplasm.