Moreover, logistic regression analysis revealed that the following clinicopathological characteristics were significantly related with lymph node metastasis in MTC patients: gender, heredity, multifocality, ETE, pT stage, and IDO2 expression level (odds ratio, 8.878; 95% CI, 4.403 to 17.902; P = 0.001; Table 4). The gene discussed is IDO2; the disease is metastatic malignant neoplasm in the lymph nodes.