This points to an interesting observation that CD8+ Tregs infiltrate this tumour model more aggressively than the CD4+ Treg counterparts, and gives wider implications, since CD8+ Tregs have been previously demonstrated to have more potent tumour suppressive functions than CD4+ Tregs (Churlaud et al. 2015; Dai et al.2014). Here, CD4 is linked to neoplasm.