Extending our analysis to other markers that may be aberrantly expressed in chronic HIV infection (TIGIT and T cell transcription factors (Eomes, T-bet))31,32, we found a significant enrichment of TIGIT+ cells within total CD8+ T cells of PLWH when compared to HIV-naïve donors (48.9% vs. 19.1%, p < 0.0001). Here, TIGIT is linked to HIV infectious disease.