For IL17RA, one of the CpG sites cg07191900 giving rise to the DMR was hypermethylated in MDD (b = 0.55, p = 4.41 × 10–7), while two other CpG sites were likewise hypermethylated (cg20758542 b = 0.45, p = 4.62 × 10–5; cg13595439 b = 0.21, p = 0.06). This evidence concerns the gene IL17RA and major depressive disorder.