In colorectal cancer cells, ISG15 upregulation by the DNA-demethylating agent 5-aza-2-deoxycytidine (5-AZA-CdR) that induces viral mimicry and targets colorectal cancer-initiating cells (CICs) indicates the role of ISG15 in the modulation of therapeutic efficacy218. This evidence concerns the gene ISG15 and colorectal cancer.