The aim of this study was to analyze a potential association between hip and knee PJI and APL and some polymorphisms of cytokines and NOS that were previously associated with inflammatory bone diseases, ([-889 C/T] IL-1α, [+ 3954 C/T, exon 5] IL-1β, [-308 G/A] TNF-α]), ([-786 T/C] NOS3 and [exon 22, NOS2]). Here, NOS2 is linked to bone inflammation disease.