Plasma IL-1β and IL-6 were significantly higher in APL IL-1β(+3954C/T, exon 5) T allele carriers compared to non-carriers (IL-1 β: 11.79 [IQR 3.41–21.14] vs. 2.11 [IQR 1.61–5.5], P < 0.03); IL-6: 43.59 [IQR 16.21–146.47 vs. 38.12 (IQR 15.0–128.7, P = 0.006]). Here, IL1B is linked to acute promyelocytic leukemia.