Enhanced serine biosynthesis by high expression of PHGDH has been reported as a metabolic pattern unique to cancer cells (cancer metabolism) [23–25] because it favors tumor cell survival by contributing to DNA and RNA methylation by S-adenosylmethionine [23] and by responding to oxidative stress by glutathione production [22] (Supplementary Fig. S3). This evidence concerns the gene PHGDH and cancer.