PHGDH and neuroblastoma: Furthermore, using another neuroblastoma cohort (GSE3446 [21]), we compared the relationship between the outcomes and PHGDH and TRPC3 expression in cases with metastasis at initial diagnosis without MYCN amplification; we found that PHGDH expression was stronger in cases with poor outcome but were not different for TRPC3 (Fig. 3C).