TXNRD1 and hepatocellular carcinoma: Further clinical data revealed negative co-expression correlations between USF2 and TXNRD1.Our data together describe a novel USF2-TXNRD1-Akt/mTOR signaling axis that regulates HCC proliferation and metastasis and provide new insight into how TXNRD1 functions in the progression of HCC (Fig. 7F).