HIF1A and hepatocellular carcinoma: To explore the molecular mechanism by which SOCS5 regulates HIF-1α, we treated HCC cells (Huh7 and Hep3B) with a GV141-SOCS5 and PI3K inhibitor (LY294002) or mTOR inhibitor (rapamycin) and then detected changes in HIF-1α protein expression.