In the knockdown SOCS5 orthotopic HCC model, we found that in the NC groups, LHAVL-induced HIF-1α expression and promoted HCC intrahepatic metastasis and lung metastasis, whereas HCC with knockdown of SOCS5 was more resistant to LHAVL-induced hypoxia and metastasis. Here, SOCS5 is linked to hepatocellular carcinoma.