To further explore the role of SOCS5 in the hypoxic tumor microenvironment, the high and low expression of SOCS5 were divided according to the median value of SOCS5 mRNA expression in the TCGA database, and hypoxia scores of HCC patients were calculated using the hypoxia score formula of Ragnum [20], Elvidge [21], and Seigneuric [22]. This evidence concerns the gene SOCS5 and hepatocellular carcinoma.