The number of lung metastatic nodules (Fig. 2B–D) and subcutaneous tumor volume and weight (Fig. 2F–H) in nude mice inoculated with HCCLM3 LV-shSOCS5 cells were significantly reduced compared with the control group, indicating that the tumor behavior of HCCLM3 cells was significantly reduced upon inhibiting SOCS5 by shRNA. The gene discussed is SOCS5; the disease is neoplasm.