In the knockdown SOCS5 orthotopic HCC model, we found that in the NC groups, LHAVL-induced HIF-1α expression and promoted HCC intrahepatic metastasis and lung metastasis, whereas HCC with knockdown of SOCS5 was more resistant to LHAVL-induced hypoxia and metastasis. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.