We collected liver left lobe HCC for IHC experiments (Fig. 7G) and found that SOCS5 was significantly higher in the NC groups than in the knockdown SOCS5 groups, and more importantly, LHAVL in the NC groups obviously promoted the expression of HIF-1α and suppressed the expression of E-cadherin, interestingly, LHAVL in the knockdown SOCS5 groups failed to obviously alter the expression of HIF-1α and E-cadherin. Here, CDH1 is linked to hepatocellular carcinoma.