Another study, examining whole blood methylation differences in psoriasis, identified three regions on chromosome-8, and chromosome-6 loci MICA, IRIF1, PSORS1C3, and TNFSF4 as hypermethylated in paternally transmitted disease, while PSORS1C1 was hypomethylated.37 The gene discussed is TNFSF4; the disease is psoriasis.