Corroborating the importance of NK cell alloreactivity, minimal NK cell cytotoxicity was observed in HLA-C/KIR matched conditions, whereas mismatched CD45dim AML blasts were efficiently killed at different E:T ratios (figure 5A, B and online supplemental sFigure 4B). The gene discussed is KIR3DL1; the disease is acute myeloid leukemia.