ccRCC is characterized by genetic features as loss of chromosome 3p, mutations in Protein Polybromo-1 gene (PBRM1), Von Hippel–Lindau (VHL), Set domain-containing 2 (SETD2) histone methyltransferase and BAP1 genes [66, 67]. Here, SETD2 is linked to nonpapillary renal cell carcinoma.