For instance, numerous studies showed that the presence of many dysregulation CRs (e.g., UHRF1, DNMT1, EZH2, BMI1 and HELLS) might lead to an abnormal epigenetic landscape in retinoblastoma (RB), which might be associated with tumorigenesis and malignant progression (10–13). This evidence concerns the gene HELLS and retinoblastoma.