Thiswas combined with a potent ATPase from potato to create an IBD treatment.In mice models of colitis, the engineered probiotic ameliorated inflammation,as observed by the lower expression of pro-inflammatory cytokines,reduced colon shortening, and improved histological scores.337 The engineered probiotic performed better thanthe probiotic with constitutively expressed ATPase and even standard-of-careIBD therapies, suggesting the therapy’s potency against inflammatorydisorders. This evidence concerns the gene DNAH8 and irritable bowel syndrome.