SHANK2 and autism: Reduction in social/non-social neuronal proportion in mPFC is a phenomenon that is shared by several autism mouse models, such as Shank2-KO (Lee et al., 2021a) and Cntnap2-KO mice (Levy et al., 2019), and therefore, may be causally related to the social impairment seen in IRSp53-KO mice.