In the analysis of TME, low expression of DLX2 was associated with various tumor-infiltrating immune-positive cells like activated CD4/CD8 T cells, memory CD4/CD8 T cells, M1, etc. Research has found activation of Wnt signaling pathway suppressed the proliferation of CD8+ memory T cells and differentiation of effector T cell, generated CD8+ memory stem cells and enhanced the polyfunctionality of memory CD8+ T cell [52–54]. This evidence concerns the gene DLX2 and neoplasm.