A large number of studies have shown that Lp-PLA2, SAA, and IgE may be involved in the occurrence of AS and the formation of vascular plaques (Liu et al., 2018; Shi et al., 2021; Fan et al., 2020; Diaconu et al., 2021; Ozben & Erdogan, 2008; Kovanen, 2007; Zhang et al., 2020; Albers et al., 2002), while the increase of the D-D level predicts thrombosis in patients (Albers et al., 2002). The gene discussed is IGHE; the disease is Venous thrombosis.