Wang et al. (2011a) and Wang et al. (2011b) found that serum IgE level in patients with coronary heart disease was significantly increased and correlated with plaque instability. IgE level is also an independent risk factor for diabetes and prediabetes Wang et al. (2011a) and Wang et al. (2011b). The gene discussed is IGHE; the disease is prediabetes syndrome.