We found that the mRNA expression levels of CRTAM, CXCL13, and LRRC15 were highly expressed in the synovial tissue of RA rats, and the protein expression of CRTAM and LRRC15 was highly expressed in the synovial tissue of RA rats, which was consistent with our previous screening results. The gene discussed is CRTAM; the disease is rheumatoid arthritis.