The diverse factors implicated in liver cancer are cellular tumor antigen p53 (TP53), axin-1 (AXIN1), catenin β-1 (CTNNB1), and telomerase reverse transcriptase (TERT) promoters as well as other primary genes for mutation generation, p53 cell cycle system, WNT/β-catenin, oxidative stress, RAS/RAF/MAPK, and PI3K/AKT/MTOR pathways along with other main primary signaling pathways. The gene discussed is TP53; the disease is liver cancer.