The high expression level of CCNB2 (logrank p = 0.052) and NDC80 (logrank p = 0.013) demonstrated poor prognosis, while HCC patients showing high level of BUB1 (logrank p = 0.001), CDK1 (logrank p = 0.00017), NCAPG (logrank p = 0.00097), BUB1B (logrank p = 0.0028), CCNB1 (logrank p = 0.00015), CDC20 (logrank p = 3.8e − 06), and MAD2L1 (logrank p = 0.0047) had a higher risk of mortality (Figure 4). The gene discussed is BUB1; the disease is hepatocellular carcinoma.