In addition, clinical researches have proved that elevated inflammatory markers, C-reactive protein (CRP), and interleukin-6 (IL-6) were associated with many complications of CKD, such as malnutrition, atherosclerosis, insulin and erythropoietin resistance, coronary artery calcification, heart disease, mineral and bone disease, anemia, and enhanced CKD mortality [6, 9–12]. Here, EPO is linked to chronic kidney disease.