Intriguingly, amongst all the TLRs studied, the expression of TLR8 mRNA transcript was most prominently upregulated at 96.6-fold (P < 0.0001) and 120.5-fold (P = 0.0001) following infection by H. pylori J99 and SS1 strains, respectively, implying a potential role of TLR8 in immunity to H. pylori. This evidence concerns the gene TLR8 and infection.