Immunofluorescence analysis of renal tissue from patients showed remarkable elevation levels of mitochondrial reactive oxygen species (mitoROS) and ROS, accompanied with increases co‐localization of NLRP3 inflammasome (NLRP3, ASC and Caspase‐1) in patients with DKD (Figure 1B–D). Here, NLRP3 is linked to diabetic kidney disease.