We unveiled a new long non‐coding RNA, Prader Willi/Angelman region RNA, SNRPN neighbour (PWARSN), which is especially expressed in proximal tubular epithelial cell (PTEC), plasma and urinary sediments samples from patients with DKD and regulated TXNIP‐induced PTECs pyroptosis in DKD. The gene discussed is TXNIP; the disease is diabetic kidney disease.