To extend this observational results in general, CAV > 100 cm3 in IPA cases also must be considered to treat with surgical intervention, unless patients have unstable hemodynamics or bleeding tendency (thrombocytopenia or prolonged prothrombin time/activated partial thromboplastin time).[3] From aspect of CT measurement, CT-volumetric analysis seems surrogate predictor of severity of IPA. This evidence concerns the gene F2 and Ito hypomelanosis.