During the formation of keloids, the hypoxia microenvironment in local tissues can induce HIF-1α Express and regulate downstream angiogenesis, inflammation, apoptosis and other biological processes.[26] Studies have shown that 2ME2 can effectively inhibit the protein expression of HIF-1α, and significantly increase the apoptosis of keloid fibroblasts induced by radiation.[27] VEGF165 in the VEGF family is the member most closely related to the proliferation and angiogenesis of vascular endothelial cells. Here, VEGFA is linked to keloid.