MMR deficiency is associated with younger age at diagnosis, endometrioid histotype, a higher proportion with Stage I disease, a higher proportion of LVSI and dedifferentiation.[23] However, Nagle CM et al reported that the risk of endometrial carcinoma is not associated with MMR status.[24] Universal tumor testing for MMR is recommended for all women diagnosed with endometrial cancer to identify those with underlying Lynch syndrome. Here, MRC1 is linked to mismatch repair cancer syndrome 1.