Decreased expression of SERPINF2 may lead to an increase in the level of activated plasmin, which will damage the stability of the fibrin bundle and thereby damage the integrity of the extracellular matrix of the liver.[22] Interestingly, the gene interactions between Proc and Serpinc1 and Plg and Serpinf2 are related to liver function and regeneration.[23] However, humans made few studies on the role of SERPINF2 in HCC, so we will further investigate it. Here, PLG is linked to hepatocellular carcinoma.