The 65-year-old female, with onset, mainly manifested facial-brachial dystonia episodes (FBDS), unresponsive, refractory hypokalemia, abnormal diffusion weighted imaging, MRI and electroencephalography, and positive anti-LGI1 and anti-mGluR5 in serum, positive anti-LGI1 in CSF. The gene discussed is GRM5; the disease is Hypokalemia.