Anti-LGI1 encephalitis is the second most common AE after anti-NMDAR encephalitis which is a type of VGKC-complex antibody encephalitis and present with limbic encephalitis.[1] It is characterized by FBDS and refractory hyponatremia in addition to the cognitive impairment, epilepsy, and psychiatric symptoms common in limbic encephalitis. This evidence concerns the gene LGI1 and epilepsy.