FGFR3 and thanatophoric dysplasia: Thanatophoric dysplasia (TD) is the most common lethal skeletal type as an autosomal dominant inherited disease caused by the mutation of the gene fibroblast growth factor receptor 3 (FGFR3), with the incidence of 2 to 3 in 1,00,000 births, and most cases die in the perinatal period.[2] The fetuses with TD in ultrasonography often show short limbs, narrow thorax, and macrocephaly with frontal bossing.