Clinical studies[13,14] have found that osteoporosis and Cushing syndrome are 2 closely related diseases, and many CS patients have decreased serum osteocalcin levels,[15] even with multiple fragility fractures as the first diagnosis.[16] Therefore, this study used bioinformatics to search for cross sections and common pathways in the vast gene networks of these 2 diseases, and predicted 340 upstream miRNAs, including 10 more critical miRNAs such as hsa-let-7a-5p, hsa-mir-30a-5p, and hsa-mir-125b-5p, which could provide potential targets for drug therapy. Here, BGLAP is linked to Cowden syndrome 1.